||Assistant Professor of Biology
Office: Baker-Hebron 13
I am committed to helping students become scientists in daily life. A student scientist
seeks knowledge open-mindedly, analyzes information critically, solves problems creatively,
and communicates conclusions effectively. These are skills that we learn in class
and apply throughout our lives. I encourage students to find topics that lead them
to further inquiry, from non-majors fulfilling general education requirements to upperclassmen
pursuing independent studies.
I believe UIU stands out through its diversity of student studies. As a member of
the biology department, my goal is to prepare you for wide variety of paths on the
whole scale of biology, from the cell to the biosphere. Whether your plan is to study
disease at the level of our cells and genes, the workings of an athlete's body, the
population ecology of a herd of deer, the health of an agricultural field, or the
conservation of our natural resources, you will find a path of study at UIU that excites
your interests and prepares you for next step.
- Principles of Biology I
- General Biology
- Cell & Molecular Biology
- Cancer Biology
- Microbial Ecology (future)
- Intro to Anatomy and Physiology
B.A. in Biology from Lawrence University, Appleton, WI
Ph.D. in Biomedical Studies--Cell Biology and Genetics from Mayo Clinic Graduate School,Rochester,
Post-Doctoral Studies in Microbiology/Immunology at National Jewish Health, Denver
- 2012-present Member, American Society of Microbiology
- 2011-present Associate Faculty Member, Faculty of 1000
- 2011-present Peer Reviewer, Public Library of Science One (PLOS One)
- 2005-present Member, American Society of Cell Biology
- Peer Reviewer, Frontiers Microbiology
I am interested in how bacteria use weapons to defend themselves from other organisms
and to attack other species. I study Listeria monocytogenes, bacteria that is normally found in the soil but which causes illness in humans when
we eat contaminated foods. Listeria secretes the protein p60 as a weapon that can manipulate our immune response during an infection, and also attack the defensive cell walls of other bacteria.
My research studies focus on how this weapon, enzyme p60, can act against bacterial
competitors that Listeria may encounter in the soil or against helpful probiotic bacteria found in fermented
foods. These studies will help us learn more about bacterial communities in the environment, in our foods, and in our own bodies. We can also apply this research
to ecological bioremediation and to improving food safety.
Examples of student projects
- Characterization preferred p60 substrates
- Evaluation p60 enzyme active site mutations
- Microbial competition and p60 expression
- Investigations of oral microbiota and dental hygiene
- Exploration of soil microbiota communities
Recent Publications and Presentations
- Sciver, R.V., Njogu, M.M., Isbell, A.J., Odanga, J.J., Bian, M., Svyatova, E., Siewertsz
van Reesema, L.L., Zheleva V., Eisner, J.L., Bruflat J.K., Schmidt, R.L.,Tang-Tan,
A.M., Tang, A.H. (2016) “Blocking SIAH proteolysis, an important K-RAS vulnerability,
to control and eradicate K-RAS-driven metastatic cancer” Book Chapter in Conquering Ras ed. Azmir, A. Elsevier.
- Qin R., Smyrk T.C., Reed N.R., Schmidt R.L., Schnelldorfer T., Chari S.T., Petersen
G.M., Tang A.H. (2015). Combining clinicopathological predictors and molecular biomarkers in the oncogenic
K-RAS/Ki67/HIF-1α pathway to predict survival in resectable pancreatic cancer. Brit. J. Cancer 112(3): 514-22.
- Schmidt, R.L. and Sheeley, S.L. (2015). Mating and memory: an educational primer for use with "epigenetic control of learning
and memory in Drosophila by Tip60 HAT action". GENETICS200:21-28.
- Schmidt, R.L. (2014) A Roadmap to Understanding Toll Pathway Changes: An Educational Primer for use with
"Regulation of Toll signaling and inflammation by β-arrestin and the SUMO protease
- Schmidt, R. L. and Lenz, L.L. (2013) "Adjuvants Targeting the DNA Sensing Pathways–
Cyclic-di-GMP and Other Cyclic-di-Nucleotides" chapter in DNA Sensing: The impact of dsDNA on Disease and Vaccinology ed. Ishi, K., and Tang, J.C.K. Elsevier.
- Schmidt, R.L. and Lenz, L.L. (2012) Distinct Licensing of IL-18 and IL-1β Secretion in Response to NLRP3 Inflammasome
Activation. Public Library of Science ONE 7(9): e45186. Epub Sept 18.
- Williams, M.A., Schmidt, R.L., Lenz, L.L. (2012) Listeria monocytogenes interactions with the innate and adaptive immune system. Trends Immunol. Oct;33(10):488-95. doi: 10.1016/j.it.2012.04.007. Epub Jun 5.
- Schmidt, R.L. and Lenz, L.L. (Sept 2012) Listeria p60 Protein and Distinct NLRP3 Inflammasome Activation. Colorado Immunology Conference. Poster Presentation
- Schmidt, R.L. Filak, H.C., Lemon, J.D., and Lenz, L.L. (Dec 2011) The Listeria p60 Protein Co-opts the Inflammasome in Mature DCs to stimulate NK cell
activation. American Society for Cell Biology Annual Meeting. Poster Presentation
- Schmidt, R.L., Filak, H.C., Lemon, J.D., Potter, T.A., Lenz, L.L. (2011) A LysM and SH3-domain containing region of the Listeria monocytogenes p60 protein
stimulates accessory cells to promote activation of host NK cells. PLOS Pathogens 7(11): e1002368. Epub Nov 3.
- Schmidt, R.L., and Lenz, L.L. (Jan 2011) The Listeria p60 Protein Stimulates NK Cells by Activating the Inflammasome in MatureDCs. NK and NKT Cell Biology Keystone Symposium. Poster Presentation
- Schmidt, R.L., Rinaldo, F.R., Hesse, S.E., Hamada, M., Ortiz, Z., Beleford, D.T.,
Page-McCaw, A., Platt, J.L., Tang, A.H. (2011) Cleavage of PGRP-LC receptor in Drosophila IMD pathway in response to live bacterial
infection in S2 cells. Self/Non-self;2(3). July/Aug/Sept (Accepted Jan 2009)
- Ahmed, A.U, Schmidt, R.L., Park C.H., Reed, N.R. Hesse, S.E., Thomas, C.F., Molina,
J.R., Deschamps, C., Yang, P., Aubry, M.C., and Tang, A.H. (2008) Effect of Disrupting Seven In Absentia Homolog 2 (Drosophila) Expression on Lung
Cancer Cell Growth. J.Natl. Cancer Inst. Nov 18;100:1606-1629.
- Schmidt, R.L, Park C.H., Ahmed, A.U., Reed, N.R., Gundelach, J.H, Knudsen, B.E., Tang,
A.H. (Dec 2008) Inhibition of K-RAS-Mediated Tumorigenesis and Metastasis by Blocking SIAH E3 Ligase-Dependent
Proteolysis in Pancreatic Cancer. American Society for Cell Biology Annual Meeting. Poster Presentation, featured
in "Novel and Newsworthy" ASCB press release
- Schmidt, R.L. (Oct 2008) Putting on the Breaks: Inhibiting Ras-mediated Tumorigenesis.Lawrence University, Appleton, WI. Recent Advances in Biology Lecture Series. Oral
- Schmidt, R.L., Trejo, T.R., Plummer, T.B., Platt, J.L., Tang, A.H. (2008) Infection-induced proteolysis of PGRP-LC controls the IMD activation and melanization
cascades in Drosophila. FASEB J. Mar;22(3):918-29. (Epub Oct 16, 2007)
- Schmidt, R.L., Ahmed, A., Park, C.H., Gundelach, J.H., Cheng S., Knudsen B. and Tang
A.H. (2007) Inhibition of RAS-Mediated Tumorigenesis by Blocking the SIAH-E3 Ligase-Dependent
Proteolysis. Cancer Res. Dec 15;67(24):11798-810.